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Subclinical affective and cognitive fluctuations in Parkinson’s disease: a randomized double-blind double-dummy study of Oral vs. Intrajejunal Levodopa

Chronic levodopa treatment in Parkinson’s disease (PD) may promote undesirable motor and non-motor fluctuations. Compared to chronic oral levodopa treatment, continuous infusion of levodopa/carbidopa intestinal gel (LCIG) in advanced PD reduces motor fluctuations. However, differences in their effect on acute non-motor changes were not formally demonstrated.