Neuropsychological deficits in patients with cognitive complaints after COVID-19
The aims of this study were to (1) explore the frequency of impaired performance across cognitive domains in post-COVID patients with subjective complaints and (2) uncover whether impairment existed within a single domain or across multiple
Characterization and management of cognitive and emotional alterations in COVID-19 critically ill patients after ICU discharge
Focusing in COVID-19 patients, is known that SARS-CoV-2 infection affects both the peripheral and the central nervous systems and is associated with a broad spectrum of neurological syndromes. Although rates of psychiatric morbidity associated with COVID-19-related brain dysfunction remain unknown, early reports suggest that non-critical SARS-CoV-2 patients suffer from attention deficits, processing speed difficulties and anomia after overcoming the disease
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
Acute obesogenic diet administration in mice impaired recognition memory due to defective production of the neurosteroid precursor pregnenolone in the hypothalamus. Genetic interference with pregnenolone synthesis by Star deletion in hypothalamic POMC, but not AgRP neurons, deteriorated recognition memory independently of metabolic disturbances.
Brain Structural Changes during Juvenile Fibromyalgia: Relationships with Pain, Fatigue and Functional Disability
Juvenile fibromyalgia (JFM) is a prevalent chronic pain condition affecting children and adolescents worldwide during a critical period of brain development. To date, no published studies have addressed the pathophysiology of JFM. Here we characterize gray matter volume (GMV) alterations in JFM patients for the first time and investigate their functional and clinical relevance
Sex Differences in Brain and Cognition in de novo Parkinson’s Disease
Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson’s disease (PD) patients
Is the effect of cognitive reserve in longitudinal outcomes in first-episode psychoses dependent on the use of cannabis?
The aim of this study was to evaluate the differences in clinical presentation according to the use of cannabis (cannabis users vs non-users) among patients presenting a FEP (non-affective vs affective psychosis), to investigate the impact of CR and cannabis use on several outcomes and to explore the potentially mediatory role played by CR in the relationship between cognitive domains or clinical status and functionality, depending on the use of cannabis.
Use of transcranial magnetic stimulation for studying the neural basis of numerical cognition: A systematic review
This systematic review aimed to synthesize the evidence that different TMS protocols provide regarding the neural basis of numerical cognition in healthy adults.
Measuring the functional impact of cognitive impairment in Huntington’s disease
The study aimed to address the need for a brief and specifically developed HD questionnaire able to capture functional aspects suspected to be sensitive to cognitive impairment.
Automated text-level semantic markers of Alzheimer’s disease
Automated speech analysis has emerged as a scalable, cost-effective tool to identify persons with Alzheimer’s disease dementia (ADD). Yet, most research is undermined by low interpretability and specificity.
Cognitive Impairment in Genetic Parkinson’s Disease
In this review, we summarize data regarding cognitive function on clinical studies, neuroimaging, and biological markers of cognitive decline in autosomal dominant PD linked to mutations in LRRK2 and SNCA, autosomal recessive PD linked to Parkin and PINK1, and also PD linked to GBA mutations.
